HESS (Heritability Estimation from Summary Statistics) is a software package for estimating and visualizing local SNP-heritability and genetic covariance (correlation) from GWAS summary association data. The latest version is version 0.5.3-beta. Reference panel can be downloaded here.

Software requirement

For running HESS

For running analysis and visualization tools

( Note: It is important to use the latest version of NumPy, which is more numerically stable when performing eigendecomposition of the LD matrix. Python 3.0+ may not work well ith HESS, which is written and tested in Python 2.7.3. )