HESS (Heritability Estimation from Summary Statistics) is a software package for estimating and visualizing local SNP-heritability and genetic covariance (correlation) from GWAS summary association data. The latest version is version 0.5.3-beta. Reference panel can be downloaded here.
For running HESS¶
For running analysis and visualization tools¶
- Local SNP-heritability: Shi, Huwenbo, Gleb Kichaev, and Bogdan Pasaniuc. "Contrasting the genetic architecture of 30 complex traits from summary association data." The American Journal of Human Genetics 99, no. 1 (2016): 139-153.
- Local genetic covariance (correlation): Shi, Huwenbo, Nicholas Mancuso, Sarah Spendlove, and Bogdan Pasaniuc. "Local genetic correlation gives insights into the shared genetic architecture of complex traits." The American Journal of Human Genetics 101, no. 5 (2017): 737-751.
- Huwenbo Shi: shihuwenbo_AT_ucla.edu
- Bogdan Pasaniuc: bpasaniuc_AT_mednet.ucla.edu